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Chromosomes of breast cancer

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News has named Jefferson among the best hospitals in the nation for Cancer care. If you suspect that you may be predisposed to breast cancer, turn to the experts of the Clinical Cancer Genetics Service at Thomas Jefferson University Hospital. Our genetics experts are dedicated to identifying and managing individuals with a known or suspected inherited predisposition to cancer. The Service is staffed by a multidisciplinary team that includes genetic counselors, oncology nurses, surgeons, molecular geneticists and a clinical geneticist.
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Chromosomes of breast cancer
Chromosomes of breast cancer
Chromosomes of breast cancer
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Breast Cancer Stages: 0 Through IV

Back to Health A to Z. We all carry certain genes that are normally protective against cancer. These genes correct any DNA damage that naturally happens when cells divide. BRCA genes are not the only cancer risk genes. Researchers recently identified more than new gene variants associated with an increased risk of breast, prostate and ovarian cancer.
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Non-Invasive or Invasive Breast Cancer

Seventy-two new genetic variants that contribute to the risk of developing breast cancer have been identified by a major international collaboration involving hundreds of researchers worldwide. There are some clear patterns in the genetic variants that should help us understand why some women are predisposed to breast cancer, and which genes and mechanisms are involved. Of these variants, reported today in the journals Nature and Nature Genetics , 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen-receptor negative breast cancer — the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifen. Breast cancer is caused by complex interactions between a large number of genetic variants and our environment. The inherited component of breast cancer risk is due to a combination of rare variants in genes such as BRCA1 and BRCA2 that confer a high risk of the disease, and many commoner genetic variants that each confer only a small risk.
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Breast cancer is the second most common cancer in women after skin cancer. Each year, approximately , women in the United States are diagnosed with breast cancer, and one in nine American women will develop breast cancer in her lifetime. Breast cancer is a common disease. But hereditary breast cancer - caused by a mutant gene passed from parents to their children - is rare. Estimates of the incidence of hereditary breast cancer range from between 5 to 10 percent to as many as 27 percent of all breast cancers.
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